Clinical application of rapid serial fourier-domain optical coherence tomography for macular imaging

Ophthalmology. 2006 Aug;113(8):1425-31. doi: 10.1016/j.ophtha.2006.03.020. Epub 2006 Jun 12.


Purpose: To introduce and examine the utility of a retinal imaging technique using high-speed optical coherence tomography (OCT) for creating a more complete retinal structural map to aid in the evaluation of patients with macular pathology.

Design: Prospective observational case series.

Participants: Five patients with a variety of macular pathologies.

Methods: Patients were imaged with a Fourier-domain high-speed high-resolution OCT system built at our institution. A sweeping serial OCT B-scan of the macula was acquired to create a detailed retinal structural map. The data were then used to make individual clinical observations.

Results: Rapid serial OCT B-scans produced detailed macular maps for all 5 patients. Diagnoses of imaged patients included macular hole, lamellar macular hole, regressed macular hole or macular microhole, choroidal neovascular membrane (CNV) from age-related macular degeneration, and CNV from presumed ocular histoplasmosis syndrome. Reconstructed B-scans and C-scans are shown for selected patients to illustrate the additional perspectives gained by obtaining a detailed retinal map.

Conclusions: Rapid serial Fourier-domain OCT B-scanning can be used to create a detailed retinal structural map. This technique provides additional information that can be missed on single OCT images and provides an accurate way to image large or complex lesions, and allows B-scan and C-scan reconstructions to be made that provide additional perspectives into retinal structures that may be missed using traditional imaging methods.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Choroidal Neovascularization / diagnosis
  • Choroidal Neovascularization / etiology
  • Eye Diseases / complications
  • Female
  • Fourier Analysis*
  • Histoplasmosis / complications
  • Humans
  • Macula Lutea*
  • Male
  • Prospective Studies
  • Retinal Diseases / diagnosis*
  • Retinal Perforations / diagnosis
  • Tomography, Optical Coherence*