Expanding role of AMPK in endocrinology

Trends Endocrinol Metab. 2006 Jul;17(5):205-15. doi: 10.1016/j.tem.2006.05.006.

Abstract

Adenosine 5' monophosphate-activated protein kinase (AMPK) is a regulator of cellular and systemic energy homeostasis. It mediates some of the effects of peripheral hormones such as leptin, ghrelin and adiponectin, and it is involved in the insulin-sensitizing role of the antidiabetic drug metformin. There is increasing evidence that AMPK has a central role in mediating the appetite-modulating and metabolic effects of many other hormones and substances, including the cannabinoids. Recent studies have illustrated the interaction between hormones and AMPK, and highlighted AMPK as a potential target for the development of tissue-specific AMPK modulators in the treatment of obesity and the metabolic syndrome.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • AMP-Activated Protein Kinases
  • Adiponectin / physiology
  • Animals
  • Appetite Regulation / physiology
  • Cannabinoids / biosynthesis
  • Cannabinoids / pharmacology
  • Cytokines / metabolism
  • Endocrine System / physiology*
  • Fatty Acid Synthases / physiology
  • Ghrelin
  • Glucose / metabolism
  • Glucose / pharmacology
  • Humans
  • Hypothalamic Hormones / physiology
  • Insulin / pharmacology
  • Leptin / physiology
  • Metformin / pharmacology
  • Models, Biological
  • Multienzyme Complexes / physiology*
  • Peptide Hormones / physiology
  • Protein-Serine-Threonine Kinases / physiology*
  • Receptors, Adrenergic / metabolism
  • Resistin / physiology
  • Rosiglitazone
  • Thiazolidinediones / pharmacology
  • Thioctic Acid / physiology

Substances

  • Adiponectin
  • Cannabinoids
  • Cytokines
  • Ghrelin
  • Hypothalamic Hormones
  • Insulin
  • Leptin
  • Multienzyme Complexes
  • Peptide Hormones
  • Receptors, Adrenergic
  • Resistin
  • Thiazolidinediones
  • Rosiglitazone
  • Thioctic Acid
  • Metformin
  • Fatty Acid Synthases
  • Protein-Serine-Threonine Kinases
  • AMP-Activated Protein Kinases
  • Glucose