Reactivation of toxoplasma retinochoroiditis under atovaquone therapy in an immunocompetent patient

Ocul Immunol Inflamm. 2006 Jun;14(3):185-7. doi: 10.1080/09273940600659740.


Purpose: To report a case of toxoplasma retinochoroiditis reactivation in an immunocompetent patient under atovaquone therapy.

Methods: Case report.

Results: A healthy woman with a history of bilateral toxoplasma retinochoroiditis since childhood presented with a reactivation of toxoplasma retinochoroiditis. Because earlier treatment regimens had either produced intolerable side effects and/or were deemed ineffective for the prevention of reactivation, the patient was started on atovaquone suspension (750 mg three times a day). After initial regression of the lesion and still under atovaquone therapy, the patient presented again five weeks later with worsened best-corrected visual acuity. Examination showed that the lesion had expanded again and more cells were present in the vitreous.

Conclusions: To our knowledge, this is the first report of a reactivation of toxoplasma retinochoroiditis in an immunocompetent patient under atovaquone therapy, possibly indicating tachyzoite resistance to atovaquone.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Animals
  • Antibodies, Protozoan / analysis
  • Antiprotozoal Agents / therapeutic use*
  • Atovaquone
  • Chorioretinitis / drug therapy
  • Chorioretinitis / immunology
  • Chorioretinitis / parasitology*
  • Drug Resistance, Microbial
  • Female
  • Humans
  • Immunocompetence*
  • Naphthoquinones / therapeutic use*
  • Oxidoreductases
  • Recurrence
  • Toxoplasma / immunology
  • Toxoplasmosis, Ocular / drug therapy
  • Toxoplasmosis, Ocular / immunology
  • Toxoplasmosis, Ocular / parasitology*
  • Visual Acuity


  • Antibodies, Protozoan
  • Antiprotozoal Agents
  • Naphthoquinones
  • Oxidoreductases
  • Atovaquone