Genome Sequence of the Cat Pathogen, Chlamydophila Felis

DNA Res. 2006 Feb 28;13(1):15-23. doi: 10.1093/dnares/dsi027. Epub 2006 Mar 3.

Abstract

Chlamydophila felis (Chlamydia psittaci feline pneumonitis agent) is a worldwide spread pathogen for pneumonia and conjunctivitis in cats. Herein, we determined the entire genomic DNA sequence of the Japanese C. felis strain Fe/C-56 to understand the mechanism of diseases caused by this pathogen. The C. felis genome is composed of a circular 1,166,239 bp chromosome encoding 1005 protein-coding genes and a 7552 bp circular plasmid. Comparison of C. felis gene contents with other Chlamydia species shows that 795 genes are common in the family Chlamydiaceae species and 47 genes are specific to C. felis. Phylogenetic analysis of the common genes reveals that most of the orthologue sets exhibit a similar divergent pattern but 14 C. felis genes accumulate more mutations, implicating that these genes may be involved in the evolutional adaptation to the C. felis-specific niche. Gene distribution and orthologue analyses reveal that two distinctive regions, i.e. the plasticity zone and frequently gene-translocated regions (FGRs), may play important but different roles for chlamydial genome evolution. The genomic DNA sequence of C. felis provides information for comprehension of diseases and elucidation of the chlamydial evolution.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptation, Biological
  • Animals
  • Bacterial Outer Membrane Proteins / genetics
  • Bacterial Proteins / genetics
  • Base Sequence
  • Cat Diseases / microbiology*
  • Cats
  • Chlamydophila Infections / veterinary*
  • Chlamydophila pneumoniae / genetics*
  • Evolution, Molecular
  • Female
  • Gene Frequency
  • Gene Transfer, Horizontal
  • Genome, Bacterial*
  • Models, Genetic
  • Molecular Sequence Data
  • Phosphoproteins / genetics
  • Phylogeny
  • Plasmids
  • Pneumonia, Bacterial / microbiology*
  • Pneumonia, Bacterial / veterinary*
  • Sequence Homology, Nucleic Acid
  • Translocation, Genetic

Substances

  • Bacterial Outer Membrane Proteins
  • Bacterial Proteins
  • IncA protein, bacteria
  • Phosphoproteins

Associated data

  • GENBANK/AP006861
  • GENBANK/AP006862