Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model

Nat Med. 2006 Jul;12(7):801-8. doi: 10.1038/nm1423. Epub 2006 Jun 11.


When given orally to a transgenic mouse model of Alzheimer disease, cyclohexanehexol stereoisomers inhibit aggregation of amyloid beta peptide (Abeta) into high-molecular-weight oligomers in the brain and ameliorate several Alzheimer disease-like phenotypes in these mice, including impaired cognition, altered synaptic physiology, cerebral Abeta pathology and accelerated mortality. These therapeutic effects, which occur regardless of whether the compounds are given before or well after the onset of the Alzheimer disease-like phenotype, support the idea that the accumulation of Abeta oligomers has a central role in the pathogenesis of Alzheimer disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / genetics*
  • Alzheimer Disease / prevention & control
  • Amyloid beta-Protein Precursor / chemistry*
  • Amyloid beta-Protein Precursor / drug effects
  • Animals
  • Cyclohexanols / antagonists & inhibitors*
  • Disease Models, Animal
  • Memory / drug effects
  • Memory / physiology
  • Mice
  • Mice, Transgenic
  • Nootropic Agents / therapeutic use
  • Phenotype
  • Plaque, Amyloid / drug effects
  • Plaque, Amyloid / pathology
  • Synapses / pathology
  • Synapses / physiology


  • Amyloid beta-Protein Precursor
  • Cyclohexanols
  • Nootropic Agents