Secondary transmission of varicella vaccine virus in a chronic care facility for children

J Pediatr. 2006 Jun;148(6):842-4. doi: 10.1016/j.jpeds.2006.01.038.


A 16-year-old varicella-seronegative resident at a chronic care facility received varicella vaccine; 15 days later he developed severe varicella. Subsequently, a 13-year-old resident and a 39-year-old health care worker developed mild varicella. We demonstrate that vaccine-strain virus was transmitted to both persons, and that transmission included at least 2 variant vaccine strains.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Chickenpox / genetics
  • Chickenpox / transmission*
  • Chickenpox Vaccine / adverse effects*
  • Chickenpox Vaccine / immunology
  • Child
  • Cross Infection / transmission*
  • Cross Infection / virology
  • Female
  • Humans
  • Immunocompetence
  • Infectious Disease Transmission, Patient-to-Professional*
  • Male
  • Point Mutation
  • Residential Facilities*


  • Chickenpox Vaccine