Anti-aminoacyl-tRNA synthetase antibodies in clinical course prediction of interstitial lung disease complicated with idiopathic inflammatory myopathies

Autoimmunity. 2006 May;39(3):233-41. doi: 10.1080/08916930600622884.


In the treatment of polymyositis and dermatomyositis (PM/DM), the complication of interstitial lung disease (ILD) is an important prognostic factor. It has been reported that autoantibodies against aminoacyl-tRNA synthetases (ARS) are strongly associated with ILD. The aim of this study is to examine the correlation between anti-ARS and the clinical course of ILD. We investigated 41 cases of PM/DM with ILD. The response of ILD to corticosteroids (CS) was determined according to the change in respiratory symptoms, image findings, and pulmonary function between, before and 2 months after the treatment. Anti-ARS (anti-Jo-1, PL-7, PL-12, EJ, OJ and KS) antibodies were screened with the RNA immunoprecipitation assay. In the stratification into ILD-preceding, simultaneous and myopathy-preceding types, anti-ARS antibodies were significantly frequent in the ILD-preceding type (p < 0.05). In the stratification into anti-ARS-positive and negative groups, the response of ILD to CS was significantly better in the positive group (p < 0.05). However, recurrence of ILD was significantly more frequent in the positive group (p < 0.01), and 2 year prognoses of pulmonary function (%VC and %DLCO) were not different between the two groups. In conclusion, screening of anti-ARS may be useful to predict late-onset myopathy in ILD-preceding patients and to predict the clinical course of ILD in PM/DM patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Amino Acyl-tRNA Synthetases / immunology*
  • Anti-Inflammatory Agents / administration & dosage
  • Autoantibodies / blood*
  • Female
  • Humans
  • Immunoprecipitation
  • Lung Diseases, Interstitial / complications*
  • Lung Diseases, Interstitial / drug therapy
  • Lung Diseases, Interstitial / physiopathology*
  • Male
  • Middle Aged
  • Myositis / complications*
  • Myositis / diagnosis
  • Myositis / physiopathology
  • Prednisolone / administration & dosage


  • Anti-Inflammatory Agents
  • Autoantibodies
  • Prednisolone
  • Amino Acyl-tRNA Synthetases