Acute symptomatic seizures and hippocampus damage: DWI and MRS findings

Neurology. 2006 Jun 13;66(11):1732-5. doi: 10.1212/01.wnl.0000218207.18707.f4.

Abstract

The authors describe diffusion-weighted imaging (DWI) and magnetic resonance spectroscopy (MRS) changes in the hippocampus within 48 hours of acute symptomatic seizures or status epilepticus in 12 patients. DWI showed increased signal and a decreased apparent diffusion coefficient (ADC) in all patients, with corresponding lactate detected on MRS in six patients and EEG seizure activity in nine patients. On follow-up, the atrophic hippocampus had an increased ADC in six patients. DWI and MRS may predict development of hippocampal sclerosis.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Atrophy / diagnosis
  • Child
  • Diffusion Magnetic Resonance Imaging / methods*
  • Female
  • Hippocampus / pathology*
  • Humans
  • Magnetic Resonance Spectroscopy / methods*
  • Male
  • Middle Aged
  • Sclerosis
  • Seizures / complications*
  • Seizures / diagnosis*