Mechanisms regulating the ductus arteriosus

Biol Neonate. 2006;89(4):330-5. doi: 10.1159/000092870. Epub 2006 Jun 1.


A patent ductus arteriosus (PDA) results in increased pulmonary blood flow and redistribution of flow to other organs. Several co-morbidities (i.e., necrotizing enterocolitis, intracranial hemorrhage, pulmonary edema/hemorrhage, bronchopulmonary dysplasia, and retinopathy) are associated with the presence of a PDA, but whether or not a PDA is responsible for their development is still unclear. In this review, comparative physiology between the full term and preterm newborn and the barriers preventing the necessary cascade of events leading to permanent constriction of the PDA are reviewed.

Publication types

  • Review

MeSH terms

  • Animals
  • Ductus Arteriosus / abnormalities
  • Ductus Arteriosus / anatomy & histology
  • Ductus Arteriosus / embryology*
  • Ductus Arteriosus / metabolism
  • Ductus Arteriosus, Patent / embryology*
  • Humans
  • Lung / blood supply
  • Regional Blood Flow