Three-component synthesis of dialkyl 2-(alkylimino-methylene)3- (2,2,5-trimethyl-4,6-dioxo-1,3-dioxan-5-yl)-succinates

Mol Divers. 2006 May;10(2):247-50. doi: 10.1007/s11030-005-9010-4. Epub 2006 Jun 13.

Abstract

The adduct produced in the reaction between alkyl isocyanides and dialkyl acetylenedicarboxylates was trapped by 2,2,5-trimethyl-1,3-dioxane-4,6-dione (methyl Meldrum's acid), to afford highly functionalized ketenimines in good yields.

Publication types

  • Comparative Study

MeSH terms

  • Alkynes
  • Combinatorial Chemistry Techniques*
  • Cyanides / chemistry*
  • Dioxanes / chemistry*
  • Fatty Acids, Unsaturated / chemistry*
  • Succinates / chemical synthesis*

Substances

  • Alkynes
  • Cyanides
  • Dioxanes
  • Fatty Acids, Unsaturated
  • Succinates
  • 2-butynedioic acid
  • Meldrum's acid