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Review
. 2006 May;64(5 Pt 2):S34-43; discussion S72-91.
doi: 10.1301/nr.2006.may.s34-s43.

Long-lasting Neural and Behavioral Effects of Iron Deficiency in Infancy

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Free PMC article
Review

Long-lasting Neural and Behavioral Effects of Iron Deficiency in Infancy

Betsy Lozoff et al. Nutr Rev. .
Free PMC article

Abstract

Infants are at high risk for iron deficiency and iron-deficiency anemia. This review summarizes evidence of long-term effects of iron deficiency in infancy. Follow-up studies from preschool age to adolescence report poorer cognitive, motor, and social-emotional function, as well as persisting neurophysiologic differences. Research in animal models points to mechanisms for such long-lasting effects. Potential mechanisms relate to effects of iron deficiency during brain development on neurometabolism, myelination, and neurotransmitter function.

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