Strumpell's disease in a family with hereditary focal segmental glomerulosclerosis

Ren Fail. 2006;28(4):351-4. doi: 10.1080/08860220600577767.


Strumpell's familial spastic paraplegia is a rare hereditary disease, clinically characterized by progressive disturbance of gait. Focal Segmental Glomerulosclerosis (FSGS) is a frequent glomerulopathy, with an extremely rare familial subtype. The cases of two brothers with Strumpell' s disease are reported, who also developed glomerular renal disease, most probably familial FSGS. The genetics of the two disorders, Strumpell's paraplegia and familial FSGS, are discussed, together with the possibility of a parallel transmission.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Glomerulosclerosis, Focal Segmental / genetics*
  • Glomerulosclerosis, Focal Segmental / pathology
  • Glomerulosclerosis, Focal Segmental / therapy
  • Humans
  • Immunohistochemistry
  • Kidney Failure, Chronic / genetics*
  • Kidney Glomerulus / pathology*
  • Kidney Transplantation
  • Male
  • Renal Dialysis
  • Spastic Paraplegia, Hereditary / genetics*