Influence of pharmacokinetics/pharmacodynamics of antibacterials in their dosing regimen selection

Expert Rev Anti Infect Ther. 2006 Jun;4(3):479-90. doi: 10.1586/14787210.4.3.479.

Abstract

The choice of antimicrobial dosing in clinical practice in the past was based upon a 'penicillin mentality', that is, on the assumption that the in vivo antimicrobial efficacy is dependent on the duration of drug levels above the minimum inhibitory concentration of target microorganisms. Really, a rational antimicrobial therapy is strongly related to a basic understanding of the influence the patient has on the antibiotic (pharmacokinetics [PKs]) and the patient's response to the specific drug effects (pharmacodynamics [PDs]). PK/PD parameters are essential in facilitating the translation of microbiological activity into clinical situations, ensuring a successful outcome. This review will analyze the typical patterns of antimicrobial activity and the corresponding PK/PD parameters, with a special focus on a PK/PD dosing approach with the most commonly utilized antimicrobial agent classes.

Publication types

  • Review

MeSH terms

  • Aminoglycosides / administration & dosage
  • Aminoglycosides / pharmacokinetics
  • Aminoglycosides / pharmacology
  • Anti-Bacterial Agents / administration & dosage*
  • Anti-Bacterial Agents / pharmacokinetics
  • Anti-Bacterial Agents / pharmacology
  • Bacterial Infections / drug therapy*
  • Fluoroquinolones / administration & dosage
  • Fluoroquinolones / pharmacokinetics
  • Fluoroquinolones / pharmacology
  • Glycopeptides / administration & dosage
  • Glycopeptides / pharmacokinetics
  • Glycopeptides / pharmacology
  • Humans
  • Ketolides / administration & dosage
  • Ketolides / pharmacokinetics
  • Ketolides / pharmacology
  • Macrolides / administration & dosage
  • Macrolides / pharmacokinetics
  • Macrolides / pharmacology

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • Fluoroquinolones
  • Glycopeptides
  • Ketolides
  • Macrolides