Studies toward soraphen A: an aldol-metathesis avenue to the macrocyclic framework

Guillaume Vincent; Darren J Mansfield; Jean-Pierre Vors; Marco A Ciufolini

doi:10.1021/ol060882s

Studies toward soraphen A: an aldol-metathesis avenue to the macrocyclic framework

Org Lett. 2006 Jun 22;8(13):2791-4. doi: 10.1021/ol060882s.

Authors

Guillaume Vincent¹, Darren J Mansfield, Jean-Pierre Vors, Marco A Ciufolini

Affiliation

¹ Laboratoire de Synthèse et Méthodologie Organiques, CNRS UMR 5181, Université Claude Bernard Lyon 1 and Ecole Supérieure de Chimie, Physique, Electronique de Lyon, Villeurbanne, France.

PMID: 16774258
DOI: 10.1021/ol060882s

Abstract

[reaction: see text] We describe a convergent approach to soraphen A, 1, that involves coupling of two fragments by an aldol condensation-olefin metathesis sequence. This route permits rapid access to congeners of 1.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Macrolides / chemical synthesis*
Macrolides / chemistry
Molecular Structure
Stereoisomerism

Substances

Macrolides
soraphen A