In vitro activity of linezolid against Mycobacterium tuberculosis complex, including multidrug-resistant Mycobacterium bovis isolates

Int J Antimicrob Agents. 2006 Jul;28(1):75-8. doi: 10.1016/j.ijantimicag.2006.02.011. Epub 2006 Jun 13.

Abstract

The activity of linezolid was studied against 55 Mycobacterium tuberculosis (42 susceptible, 3 isoniazid resistant and 10 isoniazid and rifampicin resistant), one Mycobacterium bovis and two multidrug-resistant M. bovis isolates using the standard 7H10 agar proportion and the ESP Culture System II methods. Both methods displayed similar MIC(90) values (minimum inhibitory concentrations for 90% of the organisms) of 0.5mg/L; however, the former method yielded slightly lower MIC(50) values (MICs for 50% of the organisms) (0.25mg/L) compared with the latter method (0.5mg/L). No differences were observed between susceptible and resistant isolates, including multidrug-resistant M. bovis isolates, with a MIC range of 0.12-0.5mg/L. The potential role of linezolid in tuberculosis patients requires further in vivo evaluation.

MeSH terms

  • Acetamides / pharmacology*
  • Anti-Infective Agents / pharmacology*
  • Drug Resistance, Microbial*
  • Linezolid
  • Microbial Sensitivity Tests
  • Mycobacterium bovis / drug effects*
  • Mycobacterium tuberculosis / drug effects*
  • Oxazolidinones / pharmacology*

Substances

  • Acetamides
  • Anti-Infective Agents
  • Oxazolidinones
  • Linezolid