P-bodies react to stress and nonsense

Cell. 2006 Jun 16;125(6):1036-8. doi: 10.1016/j.cell.2006.06.003.

Abstract

P-bodies are specialized cytoplasmic compartments where translational repression and mRNA turnover may occur. Findings in this issue of Cell provide evidence that P-bodies are sites of "mRNA purgatory." Bhattacharyya et al. (2006) reveal that normal mRNA can be released from P-bodies and translated into protein in response to stress. Meanwhile, Sheth and Parker (2006) report that aberrant mRNAs are targeted to P-bodies to undergo rapid decay.

Publication types

  • Comment

MeSH terms

  • 3' Untranslated Regions
  • Adaptor Proteins, Signal Transducing
  • Cationic Amino Acid Transporter 1 / genetics
  • Cationic Amino Acid Transporter 1 / metabolism*
  • Cell Line, Tumor
  • Codon, Nonsense
  • Cytoplasmic Structures / metabolism*
  • Humans
  • MicroRNAs / physiology*
  • Protein Binding
  • Protein Biosynthesis
  • RNA Helicases / genetics
  • RNA Helicases / metabolism*
  • RNA Stability
  • RNA Transport
  • RNA, Messenger / metabolism*
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism*
  • Saccharomyces cerevisiae Proteins
  • Trans-Activators / genetics
  • Trans-Activators / metabolism*

Substances

  • 3' Untranslated Regions
  • Adaptor Proteins, Signal Transducing
  • Cationic Amino Acid Transporter 1
  • Codon, Nonsense
  • MicroRNAs
  • NMD2 protein, S cerevisiae
  • RNA, Messenger
  • RNA-Binding Proteins
  • SLC7A1 protein, human
  • Saccharomyces cerevisiae Proteins
  • Trans-Activators
  • UPF3 protein, S cerevisiae
  • RNA Helicases
  • UPF1 protein, human