Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Jun 16;125(6):1165-77.
doi: 10.1016/j.cell.2006.04.036.

C. Elegans SIR-2.1 Interacts With 14-3-3 Proteins to Activate DAF-16 and Extend Life Span

Affiliations

C. Elegans SIR-2.1 Interacts With 14-3-3 Proteins to Activate DAF-16 and Extend Life Span

Ala Berdichevsky et al. Cell. .

Abstract

The longevity of Caenorhabditis elegans is promoted by extra copies of the sir-2.1 gene in a manner dependent on the forkhead transcription factor DAF-16. We identify two C. elegans 14-3-3 proteins as SIR-2.1 binding partners and show that 14-3-3 genes are required for the life-span extension conferred by extra copies of sir-2.1. 14-3-3 proteins are also required for SIR-2.1-induced transcriptional activation of DAF-16 and stress resistance. Following heat stress, SIR-2.1 can bind DAF-16 in a 14-3-3-dependent manner. By contrast, low insulin-like signaling does not promote SIR-2.1/DAF-16 interaction, and sir-2.1 and the 14-3-3 genes are not required for the regulation of life span by the insulin-like signaling pathway. We propose the existence of a stress-dependent pathway in which SIR-2.1 and 14-3-3 act in parallel to the insulin-like pathway to activate DAF-16 and extend life span.

Similar articles

See all similar articles

Cited by 151 articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback