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. 1991 Jul 29;286(1-2):233-6.
doi: 10.1016/0014-5793(91)80981-8.

Tryptase TL2 in the Membrane of Human T4+ Lymphocytes Is a Novel Binding Protein of the V3 Domain of HIV-1 Envelope Glycoprotein Gp 120

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Tryptase TL2 in the Membrane of Human T4+ Lymphocytes Is a Novel Binding Protein of the V3 Domain of HIV-1 Envelope Glycoprotein Gp 120

H Kido et al. FEBS Lett. .
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Abstract

A novel membrane-bound serine esterase in cultured human T4+ lymphocytes, recently purified and named tryptase TL2, binds specifically to the external envelope protein gp 120 of HIV-1, interacting with its V3 domain. This binding was selectively blocked by inhibitors of tryptase TL2 with a GPCR sequence in their reactive site, synthetic peptides corresponding with the sequences of the V3 domains of various HIV-1 strains with the GPGR sequence, and antibody against tryptase TL2, or neutralizing antibody against the V3 domain of HTLV-IIIB. These findings suggest that tryptase TL2 is a binding protein of the V3 domain of HIV-1 envelope glycoprotein.

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