Common Polymorphisms of Toll-Like Receptors 4 and 9 Are Associated With the Clinical Manifestation of Malaria During Pregnancy

J Infect Dis. 2006 Jul 15;194(2):184-8. doi: 10.1086/505152. Epub 2006 Jun 13.


Toll-like receptors (TLRs) are involved in recognition of and response to Plasmodium falciparum. In 304 primiparous Ghanaian women, we examined whether common TLR4 and TLR9 polymorphisms influence susceptibility to and manifestation of malaria during pregnancy. The TLR variants did not affect P. falciparum prevalence or parasite density. However, in P. falciparum-infected women, both the TLR4 Asp299Gly and the TLR9 T-1486C polymorphisms increased the risk of low birth weight in term infants 6-fold, and, additionally, TLR4 Asp299Gly increased the risk of maternal anemia 5-fold; preterm delivery was not associated with these TLR variants. These findings suggest that TLR4 and TLR9 play a role in the manifestation of malaria during pregnancy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Anemia / genetics
  • Female
  • Genetic Predisposition to Disease / genetics*
  • Ghana
  • Humans
  • Infant, Low Birth Weight
  • Infant, Newborn
  • Malaria, Falciparum / genetics*
  • Polymorphism, Genetic / genetics*
  • Pregnancy
  • Pregnancy Complications, Parasitic / genetics*
  • Toll-Like Receptor 4 / genetics*
  • Toll-Like Receptor 9 / genetics*


  • TLR4 protein, human
  • TLR9 protein, human
  • Toll-Like Receptor 4
  • Toll-Like Receptor 9