Diversity of 26-locus Y-STR haplotypes in a Nepalese population sample: isolation and drift in the Himalayas

Forensic Sci Int. 2007 Mar 2;166(2-3):176-81. doi: 10.1016/j.forsciint.2006.05.007. Epub 2006 Jun 15.


Twenty-six Y-chromosomal short tandem repeat (STR) loci were amplified in a sample of 769 unrelated males from Nepal, using two multiplex polymerase chain reaction (PCR) assays. The 26 loci gave a discriminating power of 0.997, with 59% unique haplotypes, and the highest frequency haplotype occurring 12 times. We identified novel alleles at four loci, microvariants at a further two, and nine examples of amelogenin-Y deletions (1.2%). Comparison with a similarly sized Bhutanese sample typed with the same markers suggested histories of isolation and drift, with drift having a greater effect in Bhutan. Extended (11-locus) haplotypes for the Nepalese samples have been submitted to the Y-STR Haplotype Reference Database (YHRD).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amelogenin / genetics
  • Chromosome Deletion
  • Chromosomes, Human, Y*
  • DNA Fingerprinting
  • Gene Frequency*
  • Genetics, Population*
  • Genotype
  • Haplotypes*
  • Humans
  • Male
  • Nepal
  • Polymerase Chain Reaction
  • Tandem Repeat Sequences*


  • Amelogenin