Molecular mechanisms of late endosome morphology, identity and sorting

Curr Opin Cell Biol. 2006 Aug;18(4):422-8. doi: 10.1016/ Epub 2006 Jun 15.


Recent studies using electron microscopy, protein crystallography, classic biochemistry and novel live-cell imaging have provided numerous insights into the endocytic pathway, describing a dynamic system in which compartment morphology, molecular identity and the mechanics of cargo sorting are intimately connected. Current evidence supports a model of maturation in which the lipids, cargo proteins and Rab population at the endosome determine its competence to perform the functions of late endosomes, including the sorting of cargoes into lumenal vesicles and fusion with lysosomes.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Carrier Proteins / metabolism
  • Endosomes / physiology*
  • Endosomes / ultrastructure
  • Humans
  • Lysosomes / physiology
  • Models, Biological
  • Transport Vesicles / physiology


  • Carrier Proteins