Lambda's switch: lessons from a module swap

Curr Biol. 2006 Jun 20;16(12):R459-62. doi: 10.1016/j.cub.2006.05.037.


A recent experiment has replaced Cro, a crucial component of lambda's genetic switch, with the lac repressor (plus two lac operators). The resulting hybrid phage is viable, but a subtle phenotypic defect explains a puzzle concerning the workings of the switch.

MeSH terms

  • Bacteriophage lambda / genetics*
  • Bacteriophage lambda / physiology
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Evolution, Molecular
  • Gene Expression Regulation, Viral*
  • Models, Genetic
  • Operator Regions, Genetic
  • Repressor Proteins / genetics
  • Repressor Proteins / metabolism*
  • Viral Proteins / genetics
  • Viral Proteins / metabolism*
  • Viral Regulatory and Accessory Proteins


  • DNA-Binding Proteins
  • Repressor Proteins
  • Viral Proteins
  • Viral Regulatory and Accessory Proteins
  • phage repressor proteins