Why aging T cells fail: implications for vaccination

Immunity. 2006 Jun;24(6):663-666. doi: 10.1016/j.immuni.2006.06.003.


The decline in CD4+ T cell function with aging contributes to reduced vaccine efficacy. In this commentary, we discuss the factors leading to age-related changes in T cell function and propose how they may be overcome to enhance vaccine efficacy for the elderly.

Publication types

  • Review

MeSH terms

  • Adjuvants, Immunologic / administration & dosage
  • Aging / immunology*
  • Humans
  • T-Lymphocytes / immunology*
  • Vaccination*


  • Adjuvants, Immunologic