Navigating signaling networks: chemotaxis in Dictyostelium discoideum

Curr Opin Genet Dev. 2006 Aug;16(4):333-8. doi: 10.1016/j.gde.2006.06.001. Epub 2006 Jun 19.


Studies of chemotaxis in the social amoeba Dictyostelium discoideum have revealed numerous conserved signaling networks that are activated by chemoattractants. In the presence of a uniformly distributed stimulus, these pathways are transiently activated, but in a gradient they are activated persistently and can be localized to either the front or the back of the cell. Recent studies have begun to elucidate how chemoattractant signaling regulates the three main components of chemotaxis: directional sensing, pseudopod extension, and polarization.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cell Polarity / physiology
  • Chemotaxis*
  • Dictyostelium / physiology*
  • Pseudopodia / physiology
  • Signal Transduction*