Corneal perforation due to severe peripheral ulcerative keratitis in Crohn disease

Cornea. 2006 Jun;25(5):628-30. doi: 10.1097/01.ico.0000214206.29823.2d.


Purpose: To describe corneal perforation secondary to severe peripheral ulcerative keratitis (PUK) in a patient with Crohn disease.

Methods: Interventional case report.

Results: A 72-year-old male with biopsy-proven Crohn disease presented with reduced vision, PUK, and corneal perforation in the right eye. Despite initial treatment with intravenous methylprednisolone and a conjunctival flap, a tectonic sectorial penetrating keratoplasty was required to preserve the globe and achieve a good visual result.

Conclusions: Crohn disease may be associated with severe PUK leading to corneal perforation. Tectonic corneal grafting combined with treatment of the underlying systemic disease was associated with a favorable outcome.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Combined Modality Therapy
  • Conjunctiva / surgery
  • Corneal Ulcer / etiology*
  • Corneal Ulcer / surgery
  • Crohn Disease / complications*
  • Crohn Disease / drug therapy
  • Glucocorticoids / therapeutic use
  • Humans
  • Keratoplasty, Penetrating
  • Male
  • Prednisolone / therapeutic use
  • Rupture, Spontaneous
  • Surgical Flaps


  • Glucocorticoids
  • Prednisolone