Cyclin D1 splice variant and risk for non-Hodgkin lymphoma

Hum Genet. 2006 Sep;120(2):297-300. doi: 10.1007/s00439-006-0212-3. Epub 2006 Jun 17.


To investigate the role of cell cycle gene variations in lymphomagenesis, we evaluated associations (odds ratios [OR] and 95% confidence intervals [CI]) in polymorphisms from seven candidate genes in 1,172 non-Hodgkin lymphoma (NHL) cases and 982 population-based controls. The cyclin D1 (CCND1) splice variant G870A (rs603965) increased NHL risk (OR(AA) = 1.4, 95% CI = 1.1-1.8, P-trend = 0.021), which was consistent for four B-cell subtypes. As CCND1 expression indicates poor NHL prognosis, our results, if true, would support its potentially dual importance in NHL etiology and survival.

Publication types

  • Multicenter Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Aged
  • Alternative Splicing*
  • Case-Control Studies
  • Genes, bcl-1*
  • Genetic Predisposition to Disease*
  • Humans
  • Lymphoma, Non-Hodgkin / genetics*
  • Middle Aged
  • Odds Ratio
  • Risk Factors