Treatment of erectile dysfunction in multiple sclerosis

Expert Rev Neurother. 2006 Jun;6(6):931-5. doi: 10.1586/14737175.6.6.931.


Erectile dysfunction in men with multiple sclerosis (MS) is a very common symptom that often leads to a reduced quality of life. It is related to neurological dysfunction, psychological factors, side effects of medication or generalized MS symptoms, such as fatigue or micturition problems, usually in combination. The question of sexual dysfunction should always be broached during routine follow-up, regardless of age and social status. The possibility that erection problems can be a side-effect of drugs commonly used in MS must also be remembered. There are several effective pharmacological treatments, such as phosphodiesterase inhibitors and prostaglandin E(1) (alprostadil). The contraindications and side effects should be familiar to the MS doctor. Dose titration in the initial stages is recommended to avoid priapism. In the future, combinations of impotence drugs may be tested.

Publication types

  • Review

MeSH terms

  • Alprostadil / therapeutic use
  • Apomorphine / therapeutic use
  • Dopamine Agents / therapeutic use
  • Erectile Dysfunction / drug therapy
  • Erectile Dysfunction / etiology*
  • Erectile Dysfunction / therapy*
  • Humans
  • Male
  • Multiple Sclerosis / complications*
  • Phosphodiesterase Inhibitors / therapeutic use
  • Psychotherapy
  • Vasodilator Agents / therapeutic use


  • Dopamine Agents
  • Phosphodiesterase Inhibitors
  • Vasodilator Agents
  • Alprostadil
  • Apomorphine