Immunology of normal pregnancy

Semin Fetal Neonatal Med. 2006 Oct;11(5):279-95. doi: 10.1016/j.siny.2006.04.003. Epub 2006 Jun 19.


Since Medawar's initial contemplations in 1953 on the mechanisms of immune evasion allowing for the survival of the allogeneic conceptus in an immunologically competent mother, physicians and immunologists alike have struggled to understand the immunological paradox of pregnancy. Ultimately, our attempts to define the immunology of normal pregnancy have broadened our appreciation of the myriad mechanisms at play that enable the promotion of implantation and maintenance of pregnancy. In this review, we summarise what is known regarding the immunology of normal pregnancy, with special emphasis on the relation to common disorders of pregnancy.

Publication types

  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / immunology
  • Cytokines / immunology
  • Female
  • Fetus / immunology*
  • Humans
  • Immune System / physiology*
  • Immune Tolerance
  • Immunity, Innate / physiology
  • Macrophages / immunology
  • Major Histocompatibility Complex / immunology
  • Maternal-Fetal Exchange / immunology*
  • Pregnancy
  • T-Lymphocytes / immunology
  • Trophoblasts / immunology


  • Cytokines