B-RAF mutations in the etiopathogenesis, diagnosis, and prognosis of thyroid carcinomas

Hum Pathol. 2006 Jul;37(7):781-6. doi: 10.1016/j.humpath.2006.03.013.


The very recent discovery of B-RAF point mutations as the most prevalent genetic alteration in papillary thyroid carcinoma has revolutionized the molecular knowledge of thyroid malignancies. In this review, we address the role played by such mutations in the etiopathogenesis, diagnosis, prognosis, and therapy selection of thyroid cancer, with an emphasis on papillary carcinoma.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Carcinoma, Papillary / diagnosis*
  • Carcinoma, Papillary / genetics*
  • Humans
  • Point Mutation
  • Prognosis
  • Proto-Oncogene Proteins B-raf / genetics*
  • Thyroid Neoplasms / diagnosis*
  • Thyroid Neoplasms / genetics*


  • BRAF protein, human
  • Proto-Oncogene Proteins B-raf