Biochemical studies on myelin isolated from the brains of patients with Down's syndrome

Brain. 1975 Jun;98(2):213-8. doi: 10.1093/brain/98.2.213.

Abstract

Amyelination has been deduced from the data on chemical studies of myelin isolated from the brains of Down's syndrome. The lack of cholesterol and much reduced phosphohydrolase activity in mongol myelin possibly suggest a fault in the structure of myelin.

MeSH terms

  • Adolescent
  • Adult
  • Brain Chemistry*
  • Cerebrosides / analysis
  • Cholesterol / analysis
  • Down Syndrome / metabolism*
  • Electrophoresis, Polyacrylamide Gel
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myelin Sheath / analysis*
  • Myelin Sheath / enzymology
  • Nerve Tissue
  • Phospholipids / analysis
  • Phosphoric Monoester Hydrolases / analysis
  • Proteins / analysis
  • Synaptosomes / analysis

Substances

  • Cerebrosides
  • Phospholipids
  • Proteins
  • Cholesterol
  • Phosphoric Monoester Hydrolases