Cardiac response is greater for colloid than saline fluid loading after cardiac or vascular surgery

Intensive Care Med. 2006 Jul;32(7):1030-8. doi: 10.1007/s00134-006-0195-5. Epub 2006 May 23.


Objective: To study the effects on volume expansion and myocardial function of colloids or crystalloids in the treatment of hypovolaemic hypotension after cardiac and major vascular surgery.

Design and setting: A single-centre, single-blinded, randomized clinical trial at the intensive care unit of a university hospital.

Patients and methods: Patients (n=67) were subjected to a 90-min filling pressure-guided fluid challenge with saline 0.9% or the colloids gelatin 4%, hydroxyethyl starch 6% or albumin 5%. Biochemical variables and haemodynamics (transpulmonary thermodilution) were measured.

Results: An amount of 1800 (1300-1800) ml of saline or 1600 (750-1800) ml of colloid solution (P< 0.005) was infused. Colloid osmotic pressure (COP) decreased in the saline group and increased in the colloid groups (P< 0.001). Plasma volume increased by 3.0% (-18 to 24) in the saline versus 19% (-11 to 50) in the colloid groups (P< 0.001). Cardiac index increased by median 13% (ns) in the saline group and by 22% in the colloid groups (P<0.005). The rise in left ventricular stroke work index was greater in the colloid than in the saline groups. The different colloids were equally effective. The rise in cardiac index related to the rise in plasma volume and global end-diastolic volume, confirming plasma volume and preload augmentation by the fluid loading.

Conclusion: After cardiac or major vascular surgery, the pressure- and time-guided fluid response is dependent on the type of fluid used. Colloid fluid loading leads to a greater increase in preload-recruitable cardiac and left ventricular stroke work indices than that with saline, because of greater plasma volume expansion following an increase in plasma COP.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Albumins / therapeutic use
  • Cardiac Output
  • Cardiac Surgical Procedures*
  • Crystalloid Solutions
  • Female
  • Fluid Therapy / methods*
  • Gelatin / therapeutic use
  • Humans
  • Hydroxyethyl Starch Derivatives / therapeutic use
  • Hypovolemia / etiology
  • Hypovolemia / therapy*
  • Isotonic Solutions / therapeutic use
  • Linear Models
  • Male
  • Middle Aged
  • Plasma Substitutes / therapeutic use*
  • Prospective Studies
  • Saline Solution, Hypertonic / therapeutic use
  • Treatment Outcome
  • Vascular Surgical Procedures*


  • Albumins
  • Crystalloid Solutions
  • Hydroxyethyl Starch Derivatives
  • Isotonic Solutions
  • Plasma Substitutes
  • Saline Solution, Hypertonic
  • Gelatin