Tacrolimus in steroid-resistant and steroid-dependent nephrotic syndrome

Clin Nephrol. 2006 Jun;65(6):393-400. doi: 10.5414/cnp65393.

Abstract

Background: Steroid resistance and steroid dependence constitute a major problem in the treatment of minimal-change disease and focal segmental glomerulosclerosis (FSGS). Cyclophosphamide and cyclosporine are well-established alternative immunomodulating agents, whereas data on FK 506 (tacrolimus) are rare.

Methods: The present work provides data from 10 patients of an open, monocentric, non-randomized, prospective trial. Five patients with steroid-dependent minimal-change nephrotic syndrome, 1 patient with steroid-refractory minimal-change disease and 4 patients with steroid-refractory FSGS were started on tacrolimus at trough levels of 5 10 microg/l. In case of steroid-dependence, prednisolone was tapered off in presence oftacrolimus within one month.

Results: Within 6 months, complete remission was achieved in 5 patients (50%) and partial remission in 4 patients (40%), yielding a final response rate of 90%. One patient was primarily resistent to tacrolimus (steroid-refractory minimal-change), another patient became secondarily resistant to tacrolimus after an initial remission (steroid-refractory FSGS). Average proteinuria significantly decreased by 77% from 9.5 +/- 1.4 - 2.2 +/- 1.1 g/day (p < 0.01). Serum protein significantly raised from 55.0 +/- 1.9 - 64.6 +/- 1.9 g/l (p < 0.01). Tacrolimus induced non-significant increases of blood glucose (4.9 +/- 0.1 - 5.1 +/- 0.2 mmol/l), systolic blood pressure (131.4 +/- 7.1 - 139.0 +/- 7.6 mmHg) and creatinine (93.2 +/- 13.9 103.2 +/- 15.3 mmol/l). Five patients have been tapered off tacrolimus so far, nephrotic syndrome relapsed in 4 of them (80%). Relapse occurred at tacrolimus levels between 2.6 and 6.9 ng/ml.

Conclusions: Our data suggest that tacrolimus may be a promising alternative to cyclosporine both in steroid-resistant and steroid-dependent nephrotic syndrome.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blood Glucose / analysis
  • Blood Pressure / drug effects
  • Blood Proteins / analysis
  • Creatinine / urine
  • Drug Resistance
  • Drug Therapy, Combination
  • Female
  • Glomerulosclerosis, Focal Segmental / drug therapy
  • Humans
  • Male
  • Middle Aged
  • Nephrosis, Lipoid / drug therapy
  • Nephrotic Syndrome / drug therapy*
  • Prednisolone / therapeutic use
  • Proteinuria / drug therapy
  • Steroids / pharmacology
  • Steroids / therapeutic use*
  • Tacrolimus / therapeutic use*

Substances

  • Blood Glucose
  • Blood Proteins
  • Steroids
  • Prednisolone
  • Creatinine
  • Tacrolimus