Phosphatidylinositol 4-kinases: old enzymes with emerging functions

Trends Cell Biol. 2006 Jul;16(7):351-61. doi: 10.1016/j.tcb.2006.05.003. Epub 2006 Jun 21.


Phosphoinositides account for only a tiny fraction of cellular phospholipids but are extremely important in the regulation of the recruitment and activity of many signaling proteins in cellular membranes. Phosphatidylinositol (PtdIns) 4-kinases generate PtdIns 4-phosphate, the precursor of important regulatory phosphoinositides but also an emerging regulatory molecule in its own right. The four mammalian PtdIns 4-kinases regulate a diverse array of signaling events, as well as vesicular trafficking and lipid transport, but the mechanisms by which their lipid product PtdIns 4-phosphate controls these processes is only beginning to unfold.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • 1-Phosphatidylinositol 4-Kinase / chemistry
  • 1-Phosphatidylinositol 4-Kinase / genetics
  • 1-Phosphatidylinositol 4-Kinase / physiology*
  • Animals
  • Cell Membrane / physiology*
  • Isoenzymes
  • Lipid Metabolism
  • Phosphatidylinositol Phosphates / metabolism
  • Signal Transduction
  • Transport Vesicles / metabolism


  • Isoenzymes
  • Phosphatidylinositol Phosphates
  • phosphatidylinositol 4-phosphate
  • 1-Phosphatidylinositol 4-Kinase