The human and mouse complement of SH2 domain proteins-establishing the boundaries of phosphotyrosine signaling

Mol Cell. 2006 Jun 23;22(6):851-868. doi: 10.1016/j.molcel.2006.06.001.


SH2 domains are interaction modules uniquely dedicated to the recognition of phosphotyrosine sites and are embedded in proteins that couple protein-tyrosine kinases to intracellular signaling pathways. Here, we report a comprehensive bioinformatics, structural, and functional view of the human and mouse complement of SH2 domain proteins. This information delimits the set of SH2-containing effectors available for PTK signaling and will facilitate the systems-level analysis of pTyr-dependent protein-protein interactions and PTK-mediated signal transduction. The domain-based architecture of SH2-containing proteins is of more general relevance for understanding the large family of protein interaction domains and the modular organization of the majority of human proteins.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Humans
  • Mice
  • Models, Biological*
  • Models, Molecular*
  • Phosphotyrosine / chemistry
  • Phosphotyrosine / metabolism*
  • Protein-Tyrosine Kinases / chemistry
  • Protein-Tyrosine Kinases / metabolism*
  • Sequence Analysis, Protein
  • Signal Transduction / physiology*
  • src Homology Domains / physiology*


  • Phosphotyrosine
  • Protein-Tyrosine Kinases