Is restricted randomisation necessary?

BMJ. 2006 Jun 24;332(7556):1506-8. doi: 10.1136/bmj.332.7556.1506.


Restrictions during randomisation make it easier for investigators to guess the next allocation. Statistical correction of any imbalance in confounders at the end of the study is equally accurate for most trials and would be safer

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Confounding Factors, Epidemiologic
  • Random Allocation*
  • Randomized Controlled Trials as Topic / statistics & numerical data*