Low-grade gliomas in adults

Oncologist. 2006 Jun;11(6):681-93. doi: 10.1634/theoncologist.11-6-681.


Low-grade gliomas are a heterogeneous group of neoplasms usually encountered in younger patient populations. These tumors represent a unique challenge because most patients will survive a decade or more and may be at a higher risk for treatment-related complications. Clinical observations over the years have identified a subset of low-grade gliomas that tends to manifest more aggressive clinical behavior and require earlier, more aggressive intervention. Clinical and molecular parameters may allow better assessment of prognosis and application of risk-adjusted management strategies that may include resection, radiation, or chemotherapy. Improved methods of long-term cognitive and functional assessment are desperately needed in this patient population.

Publication types

  • Review

MeSH terms

  • Brain Neoplasms* / diagnosis
  • Brain Neoplasms* / pathology
  • Brain Neoplasms* / therapy
  • Glioma* / diagnosis
  • Glioma* / pathology
  • Glioma* / therapy
  • Humans
  • Prognosis