The role of nitric oxide in tumour progression

Nat Rev Cancer. 2006 Jul;6(7):521-34. doi: 10.1038/nrc1910.


Nitric oxide (NO) and nitric oxide synthases are ubiquitous in malignant tumours and are known to exert both pro- and anti-tumour effects. We summarize our current understanding of the role of NO in tumour progression, especially in relation to angiogenesis and vascular functions. We also discuss potential strategies for cancer treatment that modulate NO production and/or its downstream signalling pathways.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Disease Progression
  • Endothelium, Vascular / metabolism
  • Humans
  • Neoplasms / blood supply
  • Neoplasms / metabolism*
  • Neovascularization, Pathologic / metabolism
  • Nitric Oxide / metabolism*
  • Nitric Oxide Synthase / metabolism
  • Signal Transduction / physiology*


  • Nitric Oxide
  • Nitric Oxide Synthase