Myelin Basic Protein: A Multifunctional Protein

Cell Mol Life Sci. 2006 Sep;63(17):1945-61. doi: 10.1007/s00018-006-6094-7.

Abstract

Myelin basic protein (MBP), the second most abundant protein in central nervous system myelin, is responsible for adhesion of the cytosolic surfaces of multilayered compact myelin. A member of the 'intrinsically disordered' or conformationally adaptable protein family, it also appears to have several other functions. It can interact with a number of polyanionic proteins including actin, tubulin, Ca(2+)-calmodulin, and clathrin, and negatively charged lipids, and acquires structure on binding to them. It may act as a membrane actin-binding protein, which might allow it to participate in transmission of extracellular signals to the cytoskeleton in oligodendrocytes and tight junctions in myelin. Some size isoforms of MBP are transported into the nucleus and thus they may also bind polynucleotides. Extracellular signals received by myelin or cultured oligodendrocytes cause changes in phosphorylation of MBP, suggesting that MBP is also involved in signaling. Further study of this very abundant protein will reveal how it is utilized by the oligodendrocyte and myelin for different purposes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cytoskeletal Proteins / metabolism
  • Humans
  • Lipids / chemistry
  • Membrane Lipids / chemistry
  • Membrane Lipids / metabolism*
  • Mice
  • Models, Biological
  • Molecular Sequence Data
  • Myelin Basic Protein / genetics
  • Myelin Basic Protein / metabolism*
  • Oligodendroglia / physiology*
  • Phosphorylation
  • Polymers / chemistry
  • Protein Isoforms / genetics
  • Protein Isoforms / metabolism
  • Protein Processing, Post-Translational*

Substances

  • Cytoskeletal Proteins
  • Lipids
  • Membrane Lipids
  • Myelin Basic Protein
  • Polymers
  • Protein Isoforms
  • polyanions