Cellular and molecular parameters of mesothelioma

J Cell Biochem. 2006 Jul 1;98(4):723-34. doi: 10.1002/jcb.20828.


Malignant mesotheliomas (MM) are neoplasms arising from mesothelial cells that line the body cavities, most commonly the pleural and peritoneal cavities. Although traditionally recognized as associated with occupational asbestos exposures, MMs can appear in individuals with no documented exposures to asbestos fibers, and emerging data suggest that genetic susceptibility and simian virus 40 (SV40) infections also facilitate the development of MMs. Both asbestos exposure and transfection of human mesothelial cells with SV40 large and small antigens (Tag, tag) cause genetic modifications and cell signaling events, most notably the induction of cell survival pathways and activation of receptors, and other proteins that favor the growth and establishment of MMs as well as their resistance to chemotherapy. Recent advances in high-throughput technologies documenting gene and protein expression in patients and animal models of MMs can now be validated in human MM tissue arrays. These have revealed expression profiles that allow more accurate diagnosis and prognosis of MMs. More importantly, serum proteomics has revealed two new candidates (osteopontin and serum mesothelin-related protein or SMRP) potentially useful in screening individuals for MMs. These mechanistic approaches offer new hope for early detection and treatment of these devastating tumors.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Asbestos / adverse effects*
  • Cell Transformation, Neoplastic
  • Cell Transformation, Viral*
  • Humans
  • Mesothelioma / diagnosis
  • Mesothelioma / etiology
  • Mesothelioma / metabolism*
  • Mesothelioma / therapy
  • Mesothelioma / virology
  • Peritoneal Neoplasms / diagnosis
  • Peritoneal Neoplasms / etiology
  • Peritoneal Neoplasms / metabolism*
  • Peritoneal Neoplasms / therapy
  • Peritoneal Neoplasms / virology
  • Pleural Neoplasms / diagnosis
  • Pleural Neoplasms / etiology
  • Pleural Neoplasms / metabolism*
  • Pleural Neoplasms / therapy
  • Pleural Neoplasms / virology
  • Polyomavirus Infections / diagnosis
  • Polyomavirus Infections / metabolism*
  • Polyomavirus Infections / therapy
  • Simian virus 40*
  • Tumor Virus Infections / diagnosis
  • Tumor Virus Infections / metabolism*
  • Tumor Virus Infections / therapy


  • Asbestos