Regulation of peripheral B cell maturation

Cell Immunol. 2006 Feb;239(2):92-102. doi: 10.1016/j.cellimm.2006.04.007. Epub 2006 Jun 23.


Although it is clear that the final phases of B cell maturation occur after newly formed B cells exit the bone marrow, the mechanisms underpinning the maturation, selection, and long-term survival of immature peripheral B cells remain poorly understood. Here, we review recent advances in our understanding of how B cell receptor (BCR)-mediated signaling events integrate with additional environmental cues to promote the selection and differentiation of immature B cells into functionally distinct subpopulations of mature B cells. We pay particular attention to the role of the Baff cytokine family and the Notch receptor-ligand family and their unique roles in promoting B cell survival and differentiation into follicular and marginal zone B cells.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • B-Lymphocyte Subsets / cytology*
  • B-Lymphocyte Subsets / immunology
  • B-Lymphocyte Subsets / metabolism
  • Cell Differentiation / immunology*
  • Humans
  • Receptors, Antigen, B-Cell / biosynthesis
  • Receptors, Antigen, B-Cell / physiology
  • Signal Transduction / immunology


  • Receptors, Antigen, B-Cell