Synthesis of a Red-Shifted Fluorescence Polarization Probe for Hsp90

Bioorg Med Chem Lett. 2006 Sep 1;16(17):4515-8. doi: 10.1016/j.bmcl.2006.06.025. Epub 2006 Jun 22.

Abstract

The synthesis of a red-shifted cy3B-GM ligand and its evaluation as a fluorescence polarization probe for Hsp90 is presented.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzoquinones / chemistry*
  • Carbocyanines / chemical synthesis
  • Carbocyanines / chemistry*
  • Color
  • Fluorescence Polarization
  • Fluorescent Dyes / chemical synthesis
  • Fluorescent Dyes / chemistry*
  • HSP90 Heat-Shock Proteins / chemistry*
  • HSP90 Heat-Shock Proteins / classification
  • Lactams, Macrocyclic / chemistry*
  • Ligands
  • Molecular Structure
  • Rifabutin / chemistry*

Substances

  • Benzoquinones
  • Carbocyanines
  • Fluorescent Dyes
  • HSP90 Heat-Shock Proteins
  • Lactams, Macrocyclic
  • Ligands
  • cyanine dye 3
  • Rifabutin
  • geldanamycin