Effect of Pueraria mirifica on the sexual skin coloration of aged menopausal cynomolgus monkeys

J Reprod Dev. 2006 Aug;52(4):537-42. doi: 10.1262/jrd.18019. Epub 2006 Jun 24.


To investigate the estrogenic effect of Pueraria mirifica (PM), a Thai herbal plant that contains many phytoestrogens, sexual skin coloration was studied in cynomolgus monkeys. Aged menopausal monkeys were divided into three groups. Each group (n=3) was fed 10, 100, or 1,000 mg of PM daily. The treatment schedule was divided into three periods, a 30-day pre-treatment period, 90-day treatment period, and 60-day post-treatment period. The results show that the sexual skin exhibited reddish coloration within 24 h after PM-treatment and remained this way for the first half of the PM-feeding period. The changes in sexual skin coloration were not dose-dependent. The present results indicate that PM had estrogenic action by increasing reddish sexual skin coloration in aged menopausal monkeys.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging
  • Animals
  • Female
  • Macaca fascicularis
  • Menopause
  • Phytoestrogens / metabolism
  • Plant Extracts / metabolism
  • Plant Extracts / pharmacology*
  • Pueraria / metabolism*
  • Skin / drug effects*
  • Skin / pathology*
  • Skin Pigmentation


  • Phytoestrogens
  • Plant Extracts