Models for metal ion function in carbonic anhydrase

Nature. 1975 Dec 25;258(5537):677-82. doi: 10.1038/258677a0.

Abstract

A model catalyst is described which has properties in common with carbonic anhydrase. The model demonstrates the availability of a mechanism, previously only hypothetical, for the action of the enzyme. It also shows, however, that this mechanism alone is not adequate to produce the high activity of the enzyme.

MeSH terms

  • Acetaldehyde
  • Carbon Dioxide
  • Carbonic Anhydrases / metabolism*
  • Catalysis
  • Chemical Phenomena
  • Chemistry
  • Hydrogen-Ion Concentration
  • Hydroxides
  • Ligands
  • Models, Biological*
  • Water
  • Zinc / metabolism*

Substances

  • Hydroxides
  • Ligands
  • Water
  • Carbon Dioxide
  • Carbonic Anhydrases
  • Acetaldehyde
  • Zinc