A comprehensive nomenclature for serine proteases with homology to tissue kallikreins

Biol Chem. 2006 Jun;387(6):637-41. doi: 10.1515/BC.2006.082.


The human kallikrein locus on chromosome 19q13.3-13.4 contains kallikrein 1--the tissue kallikrein--and 14 related serine proteases. Recent investigations into their function and evolution have indicated that the present nomenclature for these proteins is inadequate or insufficient. Here we present a new nomenclature in which proteins without proven kininogenase activity are denoted kallikrein-related peptidase. Names are also given to the unique rodent proteins that are closely related to kallikrein 1.

MeSH terms

  • Chromosomes, Human, Pair 19
  • Humans
  • Sequence Homology
  • Serine Endopeptidases* / genetics
  • Terminology as Topic*
  • Tissue Kallikreins* / genetics


  • Serine Endopeptidases
  • Tissue Kallikreins