Response of Cluster Headache to Psilocybin and LSD

Neurology. 2006 Jun 27;66(12):1920-2. doi: 10.1212/01.wnl.0000219761.05466.43.

Abstract

The authors interviewed 53 cluster headache patients who had used psilocybin or lysergic acid diethylamide (LSD) to treat their condition. Twenty-two of 26 psilocybin users reported that psilocybin aborted attacks; 25 of 48 psilocybin users and 7 of 8 LSD users reported cluster period termination; 18 of 19 psilocybin users and 4 of 5 LSD users reported remission period extension. Research on the effects of psilocybin and LSD on cluster headache may be warranted.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cluster Headache / diagnosis*
  • Cluster Headache / drug therapy*
  • Female
  • Hallucinogens / therapeutic use
  • Humans
  • Lysergic Acid Diethylamide / therapeutic use*
  • Male
  • Middle Aged
  • Psilocybin / therapeutic use*
  • Retrospective Studies
  • Severity of Illness Index
  • Treatment Outcome

Substances

  • Hallucinogens
  • Psilocybin
  • Lysergic Acid Diethylamide