Mitochondrial disease in adults: a scale to monitor progression and treatment

Neurology. 2006 Jun 27;66(12):1932-4. doi: 10.1212/01.wnl.0000219759.72195.41.


The natural history of mitochondrial diseases is poorly understood, limiting our ability to offer prognostic advice to patients or to evaluate therapy. One major obstacle to improving our understanding is the lack of a clinical rating scale to monitor the extensive clinical spectrum of mitochondrial disease. In this article, the authors describe the development and validation of a practical and semiquantitative rating scale, the Newcastle Mitochondrial Disease Adult Scale.

Publication types

  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Disease Progression
  • Female
  • Health Status Indicators*
  • Humans
  • Male
  • Middle Aged
  • Mitochondrial Diseases / diagnosis*
  • Mitochondrial Diseases / therapy*
  • Outcome Assessment, Health Care / methods*
  • Prognosis
  • Quality of Life*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Surveys and Questionnaires*
  • Treatment Outcome