Amyloid load and cerebral atrophy in Alzheimer's disease: an 11C-PIB positron emission tomography study

Ann Neurol. 2006 Jul;60(1):145-7. doi: 10.1002/ana.20889.


To determine the relationship between cerebral amyloid plaque load and rates of cerebral atrophy in Alzheimer's disease. (11)C-PIB((11)C-6-OH benzothiazole)PET (positron emission tomography) findings were correlated with volumetric magnetic resonance imaging (MRI) measurements in nine subjects with mild to moderate AD. Analysis revealed a positive correlation between rates of whole brain atrophy and whole brain (p = 0.019) and regional (11)C-PIB uptake. This provides support for the central role of amyloid deposition in the pathogenesis of AD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alzheimer Disease / diagnostic imaging*
  • Alzheimer Disease / metabolism
  • Alzheimer Disease / pathology*
  • Amyloid / metabolism
  • Aniline Compounds
  • Atrophy
  • Brain / diagnostic imaging
  • Brain / metabolism
  • Brain / pathology
  • Carbon Radioisotopes
  • Cohort Studies
  • Female
  • Humans
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Positron-Emission Tomography / methods*
  • Thiazoles


  • 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
  • Amyloid
  • Aniline Compounds
  • Carbon Radioisotopes
  • Thiazoles