Dietary hydrogenated soybean oil affects lipid and vitamin E metabolism in rats

J Nutr Sci Vitaminol (Tokyo). 2006 Apr;52(2):83-8. doi: 10.3177/jnsv.52.83.

Abstract

Fatty acids containing stearic acid, which are found in hydrogenated fat, may have a detrimental effect on the cholesterol and triacylglycerol (TAG) content of plasma lipoproteins, and on the absorption of fatty acids and fat-soluble vitamins. The aim of our study was to examine the tissue concentration of lipids and vitamins A and E after feeding a hydrogenated soybean oil (HSO) diet to rats. Twenty male Sprague-Dawley rats were randomly divided into two groups, fed on coconut oil (control) and HSO, respectively in amounts corresponding to 15% of the total feed. Plasma total cholesterol, VLDL- and LDL-cholesterol, lipid peroxidation and daily excretion of the TAG and cholesterol in feces were higher in the HSO than in the control group. TAG values in plasma and liver, and HDL-cholesterol levels in plasma were lower in the HSO than in the control group. The same was true for phospholipids in plasma and for saturated fatty acids, mono- and polyunsaturated fatty acids levels in the liver and vitamin E in plasma, LDL and adipose tissue. The results of this study provide new evidence concerning the effect of dietary hydrogenated fat on lipid, TAG and vitamin E status, which are important for maintenance of good health. Consumption of dietary HSO may be associated with cardiovascular disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cholesterol / blood
  • Dietary Fats / metabolism
  • Dietary Fats / pharmacology*
  • Feces
  • Hydrogenation
  • Lipid Metabolism / drug effects*
  • Lipid Peroxidation / drug effects
  • Lipoproteins / blood
  • Liver / drug effects
  • Liver / metabolism
  • Male
  • Phospholipids / blood
  • Rats
  • Rats, Sprague-Dawley
  • Soybean Oil / metabolism
  • Soybean Oil / pharmacology*
  • Triglycerides / blood
  • Vitamin A / metabolism
  • Vitamin E / metabolism*
  • Weight Gain / drug effects

Substances

  • Dietary Fats
  • Lipoproteins
  • Phospholipids
  • Triglycerides
  • Vitamin A
  • Vitamin E
  • Soybean Oil
  • Cholesterol