Hosting the severe acute respiratory syndrome coronavirus: specific cell factors required for infection

Cell Microbiol. 2006 Aug;8(8):1211-8. doi: 10.1111/j.1462-5822.2006.00744.x. Epub 2006 Jun 27.

Abstract

As with all viruses, the severe acute respiratory syndrome coronavirus (SARS-CoV) utilizes specific host cell factors during its infection cycle. Some of these factors have been identified and are now increasingly scrutinized as targets to intervene with infection. In this brief review, we describe the current understanding of how the SARS-CoV is able to use the cellular machinery for its replication.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Membrane Glycoproteins / physiology
  • Models, Biological
  • RNA, Viral / biosynthesis
  • SARS Virus / growth & development
  • SARS Virus / pathogenicity
  • SARS Virus / physiology
  • Severe Acute Respiratory Syndrome / etiology*
  • Severe Acute Respiratory Syndrome / physiopathology
  • Severe Acute Respiratory Syndrome / virology
  • Spike Glycoprotein, Coronavirus
  • Viral Envelope Proteins / physiology
  • Virus Assembly
  • Virus Replication / physiology

Substances

  • Membrane Glycoproteins
  • RNA, Viral
  • Spike Glycoprotein, Coronavirus
  • Viral Envelope Proteins