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Comparative Study
, 95 (3), 393-7

Increased Risk of Second Malignancies After in Situ Breast Carcinoma in a Population-Based Registry

Comparative Study

Increased Risk of Second Malignancies After in Situ Breast Carcinoma in a Population-Based Registry

I Soerjomataram et al. Br J Cancer.


Among 1276 primary breast carcinoma in situ (BCIS) patients diagnosed in 1972-2002 in the Southern Netherlands, 11% developed a second cancer. Breast carcinoma in situ patients exhibited a two-fold increased risk of second cancer (standardised incidence ratios (SIR): 2.1, 95% confidence interval (CI): 1.7-2.5). The risk was highest for a second breast cancer (SIR: 3.4, 95% CI: 2.6-4.3; AER: 66 patients per 10,000 per year) followed by skin cancer (SIR: 1.7, 95% CI: 1.1-2.6; AER: 17 patients per 10,000 per year). The increased risk of second breast cancer was similar for the ipsilateral (SIR: 1.9, 95% CI: 1.3-2.7) and contralateral (SIR: 2.0, 95% CI: 1.4-2.8) breast. Risk of second cancer was independent of age at diagnosis, type of initial therapy, histologic type of BCIS and period of diagnosis. Standardised incidence ratios of second cancer after BCIS (SIR: 2.3, 95% CI: 1.8-2.8) resembled that after invasive breast cancer (SIR: 2.2, 95% CI: 2.1-2.4). Surveillance should be directed towards second (ipsi- and contra-lateral) breast cancer.


Figure 1
Figure 1
Cumulative risk of second cancer after the diagnosis of carcinoma in situ of the breast: (A) all sites, (B) breast cancer, (C) other sites excluding breast. No. at risk represented patients still at risk at the beginning of each period.
Figure 2
Figure 2
Standardised incidence ratio for second cancer among women diagnosed with breast carcinoma in situ and with invasive breast carcinoma (Soerjomataram et al, 2005a).

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